Abstract
An overdose of tazettine (TZ) has toxic side effects, which makes it extremely important to rapidly and subtly determine the TZ. In this study, double-emitting, nitrogen–phosphorus co-doped carbon quantum dots (N,P-CQDs) were prepared using cis-butenedioic acid, phosphoric acid, and p-phenylenediamine. An effective inner filter effect (IFE) can occur between TZ and N,P-CQDs, resulting in their fluorescence quench. Therefore, a ratio fluorescent probe was constructed for detecting the TZ was constructed. After optimizing the experimental conditions, the quenching efficiency showed a strong linear connection with the TZ concentration in the range of 0.01–30 µmol/L, with the detection limit of 0.002 µmol/L. This method could be satisfactorily applied to detect TZ in mouse plasma samples.
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