Abstract
High-resolution imaging of soft and weakly adsorbed biomolecules on surfaces within buffer solutions presents a big challenge in research. Here we demonstrate that a single carbon nanotube could be used as a tip for probing biomolecules in solution using atomic force microscopy (AFM). Combining the unique properties of carbon nanotube tips with the newly developed magnetically driven oscillating AFM technique, we were able to obtain molecular-level, high-resolution images of DNA molecules adsorbed on the mica surface in solution. The length and the buckling force of the single nanotube tip can be derived directly from the force-distance curve. These measurements indicate that the nanotube tip is quite resilient, and it can quickly recover to its full length after repeatedly being crashed on the surface with excess force. The well-defined tip geometry provides extraordinary resolution in AFM imaging. The application of carbon nanotubes as AFM tips could lead to breakthroughs in biological studies.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
