Abstract
Carbon nanoparticles (CNPs) have been combined with aptamer, providing a broad application in small molecule. CNPs can be quenched by small molecules and are usually applied as luminescent probes because of their photophysical characteristics. In this work, we developed a competitive analysis for antibiotic residues detection based on carbon nanoparticles (CNPs) and oligonucleotide probes. Oligonucleotide probes including oxytetracycline (OTC) aptamer was exploited for recognition OTC and was used to restore the luminescence. Tetracycline (TC), as a competitor of OTC, was utilized to quench the luminescence of CNPs and reduce the sample matrix effect. Under optimal conditions, the linear rang of OTC was 0.010~1.0 ng/mL with the relative standard deviations (RSDs) from 2.91% to 11.3%, and the limit of detection (LOD) was low to 0.002 ng/mL. Moreover, the proposal was successfully applied to analyze OTC from drink water, indicating that this approach has great potential for other small molecule analysis.
Highlights
IntroductionMultifunctional nanoparticles have been performed various functions including targeting, imaging technology, and therapy
Advances in nanotechnology development, multifunctional nanoparticles have been performed various functions including targeting, imaging technology, and therapy
Carbon nanoparticles (CNPs) were synthesized by microwave method, and glycerine and ethylenediamine were used as both carbon source and passivating agent
Summary
Multifunctional nanoparticles have been performed various functions including targeting, imaging technology, and therapy. Silver nanoparticles, silica nanoparticles and carbon nanomaterials have been investigated for widespread applications as sensors, therapeutic agents, drug delivery, optical imaging and so on. Carbon nanomaterials such as CNPs have received lots of attention due to their unique properties including self-illumination, less toxicity, versatile surface modification, green synthetic route, optical stability, and good bio-compatibility. It was found that CNPs have strong luminescence in the visible and near-infrared spectral regions with photochemically stability and nonblinking charactristic, which is greatly different from the semiconductor quantum dots[1,2] They have been considered as new sensors for applications in small molecule assay, biosensors, bioimaging, cancer therapy, and optosensors. Due to aptamers with high affinity and specificity, the proposal would excellent selectivity and the high sensitivity is resulted from the application of TC
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