Abstract
To the Editor: In their recent “Perspective”, Hughes and Pride 1 described the carbon monoxide (CO) transfer factor ( T L,CO) as the product of two primary measurements: alveolar volume ( V A) and CO transfer coefficient K CO ( T L/ V A). V A is primary in that it has a physiological identity. However, Forster 2 has pointed out that in the context of the measurement of transfer factor, the volume is merely that of the gas exchanger; it has no more physiological significance than can be attached to the volume ( V A+ V bag) that is used for the rebreathing method. Forster 2 also warned against interpreting K CO as a separate index. Its status as a primary index would have been different if Krogh 3 had been right in her belief …
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