Abstract
A pneumoperitoneum of nitrogen was set to rabbits, guinea pigs, and rats, and the CO partial pressure was measured in this tissue model of the animals, breathing 86, 300, 700, and 1000 ppm CO. After diffusion equilibrium had been reached, we obtained the following results: (1) the CO partial pressure in tissue is only 42–69% of the CO partial pressure in the inspired air; (2) the percentage CO partial pressure in tissue compared with the CO partial pressure in the inspired air is lower, the higher the CO content of the inspired air; (3) the CO partial pressure in tissue of a species of animal is lower, the higher the CO affinity of hemoglobin. These results can be explained by the competition of CO and O 2 for the receptor hemoglobin. The CO partial pressure in tissue is influenced decisively by the different CO and O 2 affinities of hemoglobin.
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