Abstract
The entity of carbon monoxide-induced Parkinsonism is reviewed. Two distinct clinical pictures are described which follow carbon monoxide exposure and which have been labeled “Parkinsonian.” Most cases previously reported showed signs of diffuse neurological involvement with some Parkinsonian features, but the individual patients' clinical manifestations did not resemble those of true Parkinsonism. A few reported cases did show a clinical course resembling that of progressive Parkinsonism following either acute or chronic exposure to carbon monoxide. A patient with severe and rapidly-progressive Parkinsonism following recurrent exposure to carbon monoxide is described. The Parkinsonian state in this patient began almost 4 years after the last known severe exposure to carbon monoxide. The patient improved remarkably when given levodopa.
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