Abstract
A patient is described who, for many years, had had attacks of headache, vertigo, muzziness, and, occasionally, loss of consciousness. The attacks were always triggered off by intensive cigarette smoking. Similar symptoms were provoked by breathing carbon monoxide in air. Capillary filtration-rate and transvascular albumin transport also rose during laboratory exposure to carbon monoxide. The patient stopped smoking 3 years ago and has since been free from attacks. It is concluded that the attacks were caused by uptake of carbon monoxide from the tobacco smoke, the pathogenesis being increased endothelial filtration and permeability.
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