Abstract
Carbon ion radiotherapy is known for its high‐precision dose distribution and high biological effectiveness. We evaluated the results of carbon ion radiotherapy in 128 patients with unresectable localized axial soft tissue sarcoma at a single institution. The patients’ median age was 54 years, and the median follow‐up period was 49.4 (range 6.4‐146.4) months. The median tumor volume was 356 cm3. The 5‐year local control, overall survival, and disease‐free survival rates were 65%, 46%, and 39%, respectively. In the univariate analysis, tumor volume, local control, and incidences of metastases were significantly related to overall survival. In the multivariate analysis, tumor volume and local control were significantly related to overall survival. We did not find any factors related to local control. Five patients required surgical intervention because of adverse events in the bones. Carbon ion radiotherapy may be a treatment option for unresectable axial soft tissue sarcoma.
Highlights
The main treatment option for soft tissue sarcoma (STS) is resection, and complete resection plays an important role in achieving positive oncologic results.[1,2] Radiotherapy (RT), in the case of STS, plays an auxiliary role to surgery and is applied preoperatively and/or postoperatively.[3,4] The main modalities of perioperative RT are external irradiation, intraoperative RT, and brachytherapy using photon beams
Between June 2000 and March 2015, 128 patients with localized unresectable STSs of the axis were treated with carbon ion radiotherapy (CIRT), at a single institute
Complete resection in cases of STS is important in achieving good oncologic results,[1,2,15] but only 40%-60% of deep- seated STS can be completely resected.[15,16,17,18,19]
Summary
The main treatment option for soft tissue sarcoma (STS) is resection, and complete resection plays an important role in achieving positive oncologic results.[1,2] Radiotherapy (RT), in the case of STS, plays an auxiliary role to surgery and is applied preoperatively and/or postoperatively.[3,4] The main modalities of perioperative RT are external irradiation, intraoperative RT, and brachytherapy using photon beams.
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