Carbon Disuphide Mediated Synthesis of 1,3-Benzothiazole-2(3H)-Thione Toward Inhibiting for Biodegradable Zinc Bone Implant in Bodily Fluid

Abstract

Clinical problems associated with stress shielding and secondary surgery are mostly addressed by using biodegradable implant materials as effective alternatives in dentofacial orthopedics. These implants are normally installed in between tissues of a host to rehabilitate an impaired physical function while also mimicking a desired cellular characteristic without rejection toward improved quality of life. However, some of these implants are also susceptible to corrosion. In the present study, a corrosion inhibiting 1,3-Benzothiazole-2(3H)-thione (MBT) compound is synthesized and utilized in studying metallic bone implant corrosion in simulated bodily fluid. MBT was synthesized from a CS2 mediated synthesis mechanism involving a catalyzed reaction between aminophenyl disulfide with metal sulfide under N2 atmosphere (Figure 1 a). The MBT synthesis mechanism involved the formation of a C-S bond under relatively less reaction duration and milder thermal conditions, as an alternative route to organic thiols (Figure 1 b-c). The tendency of MBT toward zinc-surface adsorption and corrosion inhibition was investigated in bodily fluid. MBT acted as a corrosion inhibitor within this medium and this was consistent with molecular adsorption and formation of MBT films on the biodegradable zinc bone implant substrate. The MBT heterocyclic molecular structure may have been the greater edge toward Zn surface adsorption, hence corrosion inhibition. The extent of interfacial interactions between MBT and the Zn layer was also theoretically examined by molecular dynamic simulations. Zn implant corrosion resulted in chloride-induced pit with a predominantly cathodic kinetics in the presence of MBT. Since molecular structure is an important aspect of sustainable corrosion inhibition design, the study reflects a modern design for alleviating corrosion in zinc bone implant. Keywords: Biodegradable zinc bone implant; 2-mercaptobenzothiazole; CS2 mediated synthesis, Zinc corrosion; Corrosion inhibition. Figure 1