Abstract
Carbon dioxide (CO2) laser therapy for vulvar intraepithelial neoplasia (VIN) is a very accurate method of treatment, giving excellent cosmetic results. Forty-three women diagnosed as suffering from VIN were treated by means of the CO2 laser. In 19 of 26 premenopausal patients, VIN was associated with histologic evidence of human papillomavirus (HPV) infection (73.1%). In only 2 of 17 postmenopausal women, such evidence was found (11.8%)—a statistically significant difference. Five women experienced recurrence of the disease. Four were premenopausal, and all had association with HPV infection. In one postmenopausal patient, no signs of HPV were found. We conclude that the association of HPV with the diagnosis of VIN has a deleterious effect on treatment results.
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