Abstract

The information explosion has led to a rapid increase in the amount of data requiring physical storage. However, in the near future, existing storage methods (i.e., magnetic and optical media) will be insufficient to store these exponentially growing data. Therefore, data scientists are continually looking for better, more stable, and space-efficient alternatives to store these huge datasets. Because of its unique biological properties, highly condensed DNA has great potential to become a storage material for the future. Indeed, DNA-based data storage has recently emerged as a promising approach for long-term digital information storage. This review summarizes state-of-the-art methods, including digital-to-DNA coding schemes and the media types used in DNA-based data storage, and provides an overview of recent progress achieved in this field and its exciting future.

Highlights

  • Introduction toDNA-based data storageThe concept of DNA-based data storage was introduced by computer scientists and engineers in the 1960s [1]

  • Since there are currently no systematic studies on storage media, we introduced some representative works which employed in vivo and in vitro strategy, and showed their comparative description

  • We chronologically presented various coding schemes, we tried to deliver the information that all the coding schemes made improvement based on these two ways

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Summary

Availability of data and materials

All datasets and code on which the conclusions of the paper rely must be either included in your submission or deposited in publicly available repositories (where available and ethically appropriate), referencing such data using a unique identifier in the references and in the “Availability of Data and Materials” section of your manuscript. Have you have met the above requirement as detailed in our Minimum Standards Reporting Checklist?. 1 †These authors contributed to this work

16 Introduction to DNA-based data storage
24 Overview of current coding schemes for DNA-based data storage
21 In vivo DNA-based data storage
16 In vitro DNA-based data storage
12 Challenges of DNA-based data storage
24 Perspectives on DNA-based data storage
18 Acknowledgements
23 Figure legends
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