Abstract
A series of carbohydroxamido-oxazolidine inhibitors of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase, the enzyme responsible for the second step in lipid A biosynthesis, was identified. The most potent analog L-161,240 showed an IC 50 = 30 nM in the DEACET assay and displayed an MIC of 1∼3 μg/mL against wild-type E. coli.
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