Carbohydrate scaffolds for combinatorial syntheses that allow selective deprotection of all four positions independent of the sequence.

Abstract

Irrespective of the sequence, the carbohydrate scaffold 1 as a molecular platform for combinatorial diversification can be selectively deprotected and equipped with side chains, for example amino acids or peptides, in every position (see picture). This allows the flexible arrangement of functional groups and structural elements. PG=protective group.