Abstract
Carbohydrate Metabolism: Glycogen Phosphorylase and the Work of Carl F. and Gerty T. Cori
Highlights
After nine generally happy and productive years in Buffalo, the Coris began to feel uncomfortable that their growing interest in carbohydrate metabolism did not fit the cancer research mission of the Institute
Louis marked a transition for the Coris from physiology to biochemistry. These Journal of Biological Chemistry (JBC) Classics were selected in an attempt to represent the breadth of their work
In the second Classic, the investigation of glycogen breakdown in minced frog muscle had become biochemical. They had already described the “Cori ester,” glucose 1-phosphate, as a breakdown product of glycogen. They described phosphoglucomutase, the enzyme that converts glucose 1-phosphate to glucose 6-phosphate, which is necessary for subsequent metabolism
Summary
Carbohydrate Metabolism: Glycogen Phosphorylase and the Work of Carl F. and Gerty T. The Activity of the Phosphorylating Enzyme in Muscle Extracts Life in Vienna was very difficult after World War I, with near starvation conditions, yet the Coris found work in clinical laboratories and even found some time for research.
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