Carbohydrate intake and the risk of prostate cancer

Abstract

BackgroundProstate cancer (PCa) is one of the leading cause cancer among men worldwide. Many epidemiologic studies have reported an association between carbohydrate intake and PCa. However, the evidence from epidemiologic studies is inconsistent. We conducted a comprehensive meta-analysis to explore the associations between carbohydrate intake and PCa risk and to investigate potential dose–response relationships. MethodsWe searched PubMed and EMBASE for studies published from 1980 to 2018. 21 studies were included with 98,739 participants and 11,573 cases. Multivariate-adjusted odds ratios (ORs) were pooled using random-effect models. Potential dose–response relationships were evaluated for PCa risk. ResultsWe did not detect an association about higher carbohydrate intake and PCa risk (OR:1.11, 95% confidence interval [CI]: 0.98–1. 26, I2 = 62.7%), nor association was detected about higher carbohydrate intake with advanced PCa risk (OR:0.95, 95% CI: 0.78–1.16, I2 = 14.1%) or non-advanced Pca risk (OR:1.01, 95% CI: 0.79–1.29, I2 = 64.4%). There was not a significant dose–response association observed for carbohydrate intake with PCa risk and advanced PCa risk. ConclusionsOur meta-analysis shows no association between carbohydrate intake and prostate cancer risk. Nor is association detected about carbohydrate intake with advanced or non-advanced Pca risk. More studies are needed for a further dose-response meta-analysis.