Carbohydrate Derived Fulvic Acid (CHD-FA) is a Novel Antifungal Product: Category: Scientific free paper

Abstract

• Ala-Nap was added at a final concentration of 64mg/L, and the relative fluorescence measured for every 30s for 1 hour. • Isolates standardised to 1 × 106 and 1 x 10 7 cells for sessile and planktonic respectively, in assay buffer solution., and added to a black flat bottomed micro-titre plate. The aim of this study was to evaluate the antimicrobial activity of CHD-FA against a range of Candida albicans isolates associated with mucosal and systemic candidiasis. In addition, the toxicological properties of the compound were evaluated. The oral cavity contains a diverse and complex microbial ecology, which includes yeasts growing as biofilms. Oral candidiasis is a characteristic infection commonly observed in immunocomprimised patients, especially those with an HIV infection and causes oral discomfort, pain and taste distortion [1]. Despite Candida albicans being a commensal of the oral cavity in 30-40% of healthy individuals, it is also the most common fungal pathogen in humans [2]. In addition to infections in the oral cavity, C. albicans is also responsible for infections in the ICU. Bloodstream infections caused by this organism are associated with morbidity and mortality worldwide.