Abstract
We aimed to assess the association between CA125 and the long-term risk of total acute heart failure (AHF) admissions in patients with an index hospitalization with AHF and preserved ejection fraction (HFpEF). We prospectively included 2369 patients between 2008 and 2019 in three centers. CA125 and NT-proBNP were measured during early hospitalization and evaluated as continuous and categorized in quartiles (Q). Negative binomial regressions were used to assess the association with the risk of recurrent AHF admission. The mean age of the sample patients was 76.7 ± 9.5 years and 1443 (60.9%) were women. Median values of CA125 and NT-proBNP were 38.3 (19.0–90.0) U/mL, and 2924 (1590–5447) pg/mL, respectively. During a median follow-up of 2.2 (0.8–4.6) years, 1200 (50.6%) patients died, and 2084 AHF admissions occurred in 1029 (43.4%) patients. After a multivariate adjustment, CA125, but not NT-proBNP, was positively and non-linearly associated with the risk of cumulative AHF-readmission (p < 0.001). Compared to Q1, patients belonging to Q2, Q3, and Q4 showed a stepwise risk increase (IRR = 1.29, 95% CI 1.08–1.55, p = 0.006; IRR = 1.35, 95% CI 1.12–1.63, p = 0.002; and IRR = 1.62, 95% CI 01.34–1.96, p < 0.001, respectively). In conclusion, CA125 predicted the risk of long-term AHF-readmission burden in patients with HFpEF and a recent admission for AHF.
Highlights
We aimed to assess the association between Carbohydrate antigen 125 (CA125) and the long-term risk of total acute heart failure (AHF) admissions in patients with an index hospitalization with AHF and preserved ejection fraction (HFpEF)
This study aimed to assess the association between CA125 and the risk of long-term recurrent HF-readmission in patients with HFpEF recently discharged for AHF
In this study, which included a large cohort of patients with HFpEF discharged after an episode of AHF, CA125, and not NT-proBNP predicted the long-term burden of total HF admissions
Summary
We aimed to assess the association between CA125 and the long-term risk of total acute heart failure (AHF) admissions in patients with an index hospitalization with AHF and preserved ejection fraction (HFpEF). CA125 predicted the risk of long-term AHF-readmission burden in patients with HFpEF and a recent admission for AHF. Carbohydrate antigen 125 (CA125) is a large mucin synthesized by mesothelial cells Higher values of this glycoprotein have been reported in patients with several conditions, including AHF syndromes[5]. CA125 has been independently associated with a higher risk of time to first adverse clinical outcomes in patients with AHF, mainly within the first year of follow-up[7,8]. This study aimed to assess the association between CA125 and the risk of long-term recurrent HF-readmission in patients with HFpEF recently discharged for AHF. We evaluated the association of aminoterminal pro-brain natriuretic peptide (NT-proBNP) with the same endpoint
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