Abstract
The present study aimed to investigate the histological, histochemical changes of thyroid gland in case of induced hypothyroidism by carbimazole in domestic female rabbits. Histological results revealed many histpathological changes compared with the control group there are hyperatrophy of follicular epithelium , hemorrhage ,edema and damage in the epithelium lining of the follicles. Histochemical examination of thyroid gland of control rabbits show the intensity and homogenous staining of colloid figure while the thyroid gland of female rabbits treated with CBZ for 30 days show decreased of normal distribution of glycoprotein inside follicles ,the non homogenous cord like materials and less intensity of colloid figure , also the thyroid gland of rabbits treated with CBZ for 60 days show less homogenisty of colloid or absence of colloid in some follicles
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