Abstract
In the past few years, super‐resolution microscopy techniques have already allowed imaging of biological structures at nanometer scale resolution. Nevertheless, due to the strict requirements of super-resolution optical conditions, fluorescent probes targeting specific mitochondrial structures, such as cristae, are still lacking, which constitutes a major challenge in studying mitochondrial biology. In this paper, we rationally constructed a pyridine-carbazole-based fluorescent probe that targets mitochondria with high specificity without compromising fluorescence under live, fixation and oxidative phosphorylation condition. In addition, its excellent optical properties (Large Stokes Shift, mitochondria-specific targeting under different conditions) allowed to monitor mitochondrial morphological changes in living cells using SIM super-resolution nanoscopy.
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