Abstract
Background: Acinetobacter baumannii (Ab) is an opportunistic bacterial pathogen found in hospital-acquired infections including nosocomial pneumonia, especially multidrug-resistant Ab. This study aims to survey the drug resistance profiles of Ab isolated from patients in Thong Nhat Dong Nai General Hospital and assess the relationship between genotypes and antibiotic resistance; Methods: Ninety-seven Ab strains isolated from 340 lower respiratory tract specimens among pneumonia patients were used to screen the most common local carbapenemase genes. Antimicrobial susceptibility testing results and demographic data were collected and minimum inhibitory concentrations (MIC) of colistin were also determined; Results: Over 80% and 90% of Ab strains were determined as carbapenem-resistant and multidrug-resistant (MDR), respectively. Most of the strains carried carbapenemase genes, including blaOXA-51, blaOXA-23-like, blaOXA-58-like, and blaNDM-1, with proportions of 97 (100%), 76 (78.4%), 10 (10.3%), 6 (6.2%), respectively. Amongst these genes, blaOXA-23-like was the only gene which significantly influenced the resistance (p < 0.0001); and Conclusions: The severity of Ab antibiotic resistance is urgent and specifically related to carbapenemase encoding genes. Therefore, screening of MDR Ab and carbapenemase for better treatment options is necessary.
Highlights
Acinetobacter baumannii (Ab) is an opportunistic bacterium causing serious healthcare-associated infections (HAIs) [1]
From 340 specimens, 481 bacterial strains were identified, which consist of 81.0% Gram negative bacilli
Ab was found in Enterobacteriaceae and Stenotrophomonas maltophilia), 12.0%
Summary
Acinetobacter baumannii (Ab) is an opportunistic bacterium causing serious healthcare-associated infections (HAIs) [1]. Ab) causes VAP in a high proportion of cases, more than 60% [5,6] These bacteria are resistant to most currently available antibiotics, including carbapenem, though with the exception of colistin [6]. These pathogens are resistant to colistin by means of complete loss of lipopolysaccharide production. Acinetobacter baumannii (Ab) is an opportunistic bacterial pathogen found in hospital-acquired infections including nosocomial pneumonia, especially multidrug-resistant. Nhat Dong Nai General Hospital and assess the relationship between genotypes and antibiotic resistance; Methods: Ninety-seven Ab strains isolated from 340 lower respiratory tract specimens among pneumonia patients were used to screen the most common local carbapenemase genes. Screening of MDR Ab and carbapenemase for better treatment options is necessary.
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