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Abstract
It has been suggested that severe and repeated diarrhoea may be a major factor in cataracto-genesis in some tropical countries and account for the high prevalence of cataract in these countries. At least four effects of the diarrhoeal syndrome could lead to cataract and one of these is the high concentration of urea in the blood. Urea comes to equilibrium with cyanate and in this paper we investigate the reaction of cyanate with lens proteins and report preliminary evidence that carbamylation has occurred during cataractogenesis in Pakistan.
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