Abstract
We find that a common mutation that increases angiotensin I-converting enzyme activity occurs with higher frequency in male patients suffering from refractory temporal lobe epilepsy. However, in their brains, the activity of the enzyme is downregulated. As an explanation, we surprisingly find that carbamazepine, commonly used to treat epilepsy, is an inhibitor of the enzyme, thus providing a direct link between epilepsy and the renin–angiotensin and kallikrein–kinin systems.
Highlights
Epilepsy is a chronic neurological disease characterized by abnormal neural activity leading to epileptic seizures afflicting B1% of the population worldwide
Aiming to corroborate these results, we tested directly the hypothesis that polypharmacological effects of current available drugs could have effects mediated by angiotensin Iconverting enzyme (ACE) inhibition, leading to the finding that carbamazepine, one of the most commonly used drugs in the treatment of epilepsy and psychiatric disorders is a direct inhibitor of ACE
Owing to the association between ACE and epilepsy, we examined male patients suffering from refractory temporal lobe epilepsy (TLE) for the occurrence of the common ACE insertion (I)/deletion (D) polymorphism, which is known to induce lower ACE plasma activities in II subjects.[4]
Summary
Epilepsy is a chronic neurological disease characterized by abnormal neural activity leading to epileptic seizures afflicting B1% of the population worldwide. The ACE I/D polymorphism was genotyped as described[6] in 72 patients with epilepsy who underwent surgery and 368 controls.
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