Carbamazepine, Auditory ERPs, and BCECT

J Gordon Millichap

doi:10.15844/pedneurbriefs-8-1-5

Abstract

The effects of carbamazepine (CBZ) on cognitive function were evaluated by using measurements of auditory event-related potentials (ERPs) and P300 latencies in 23 patients, aged 7 to 16 years, with benign childhood epilepsy and centrotemporal spikes (BCECT), at the Department of Pediatrics, Toyama Medical and Pharmaceutical University, Toyama, Japan.

Highlights

Hematologic side effects in 60 patients, aged 2-29 years, receiving valproate (VPA) monotherapy for >4 years in a long-term care facility, are reported from the Department of Pediatrics, East Carolina University School of Medicine, Greenville, North Carolina
CARBAMAZEPINE, AUDITORY ERPs, AND BCECT The effects of carbamazepine (CBZ) on cognitive function were evaluated by using measurements of auditory event-related potentials (ERPs) and P300 latencies in 23 patients, aged 7 to 16 years, with benign childhood epilepsy and centrotemporal spikes (BCECT), at the Department of Pediatrics, Toyama Medical and Pharmaceutical University, Toyama, Japan
As the epilepsy was controlled at the initiation of therapy, and with increasing age, the P300 latency was at first shortened

Summary

ANTICONVULSANT TOXICITY

CARBAMAZEPINE, AUDITORY ERPs, AND BCECT The effects of carbamazepine (CBZ) on cognitive function were evaluated by using measurements of auditory event-related potentials (ERPs) and P300 latencies in 23 patients, aged 7 to 16 years, with benign childhood epilepsy and centrotemporal spikes (BCECT), at the Department of Pediatrics, Toyama Medical and Pharmaceutical University, Toyama, Japan. (Naganuma Y et al Auditory event-related potentials in benign childhood epilepsy with centrotemporal spike: The effects of carbamazepine. Abnormalities in ERPs in patients with epilepsy, and prolongation of P300 latency, have been ascribed to the effects of the seizures and to antiepileptic drug therapy. Various epileptic syndromes have shown different degrees of abnormality in the ERPs. In this study, after a transient beneficial response, the cumulative effect of carbamazepine was associated with a chronic impairment of cognitive function, as measured by changes in auditory event-related potentials. CBZ has suppressive influences on central auditory structures and the acoustic nerve. (Japaridze G et al Epilepsia Nov/Dec 1993:34:1105-1109)

CARBAMAZEPINE TOXICITY WITH GENERIC SUBSTITUTION

Findings

ATTENTION DEFICIT AND COGNITIVE DISORDERS