Abstract
In the guinea pig myometrium prelabelled with myo-[2- 3H]inositol, carbachol and oxytocin enhanced a concentration-dependent and rapid release of IP 3 which preceded that of IP 2 and IP 1. The specific receptor-mediated phospholipase C activation degrading PIP 2 to IP 3 did not require the presence of extracellular Ca 2+. The ionophore A23187 as well as K + depolarization failed to increase inositol phosphate accumulation. It is proposed that IP 3 could have a role in the contraction of uterine smooth muscle elicited by the activation of muscarinic as well as of oxytocin receptors.
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