Carapa guianensis Aubl. (Meliaceae) oil associated with silk fibroin, as alternative to traditional surfactants, and active against larvae of the vector Aedes aegypti

Abstract

This paper report the use of Carapa guianensis Abul. (Meliaceae) oil and derivates [fatty acid ethyl ester (FAEE’s) and free fatty acid (FFA’s)] associate with silk fibroin (SF), and its activity against the larvae of the vector Aedes aegypti. The emulsions FFA2-SF derived from AO2, that mostly contained unsaturated fatty acids, presented the best results against the larvae of Ae. aegypti after a 48 h period (LC50 = 16.79 mg.mL−1), causing structural alterations to the vector. It is suggested that the biopolymeric matrix of silk fibroin increases the biodistribution and bioavailability of active in medium aqueous. This is the first work of its type which has pointed larvicidal activity of the free fatty acid from C. guianensis, associate with silk fibroin against Aedes aegypti.