CAR-T Cells Therapy: What Cardiovascular Adverse Effects Should We Expect?

Abstract

Immunotherapy has emerged as a specific treatment, guided by oncologic targets, that has given the false impression (to oncologists and hematologists) that it had no adverse effects, including cardiovascular complications. Chimeric antigen receptor (CAR) T-cell therapy has certainly benefited specific patients; in contrast, reports of adverse cardiovascular effects have emerged. In this paper, we conducted a narrative review of conceptual aspects, clinical applicability, the cytokine release syndrome, extracardiac AE and, above all, the cardiovascular AE of CAR-T cell therapy. [...]