Abstract

Charlotte Barker, Editor, BioInsights, speaks with Dimitrios Mougiakakos, Professor & MD, Department of Hematology & Oncology, University Hospital Magdeburg Professor Dimitrios Mougiakakos, MD has been the director of the Hematology and Oncology department at the Otto-von-Guericke University in Magdeburg, Germany since November 2021. He studied medicine in Hannover and performed his residency at the Universities of Freiburg, Regensburg, and Erlangen, Germany. During his postdoctoral studies at the Karolinska Institute in Stockholm, Sweden he focused on immunotherapeutic concepts against malignancies and against hyper-inflammatory conditions. Moreover, he has a special interest in understanding the metabolic perspective of heterocellular crosstalk and to use these insights for improving immunotherapies. Following his return to Erlangen he was strongly involved in developing and leading the local cell therapy program, where patients with refractory SLE were treated with anti-CD19 CAR-T cells for the first time.Dimitrios Mougiakakos joins us to discuss the exciting potential for CAR-T cell therapy for autoimmune disease and how his team approached GMP manufacturing in the clinical setting.

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