CAR-T Cell Therapy: Revolutionizing Cancer Treatment with Engineered Immune Cells

Abstract

CAR-T cell therapy, a revolutionary immunotherapy approach utilizes gene-engineered T cells to recognize and eliminate cancer cells. The CAR is engineered to recognize specific tumor-associated antigens, enabling T cells to effectively recognize and destroy cancer cells. Mostly, the cell for CAR-T cell therapy is collected from the patient which lead to a high individual. Then, the artificially engineered cells which express CAR, expand and culture in the laboratory. Finally, the CAR-T cells are sent back into the patient. This personalized therapy has shown remarkable success in treating hematological malignancies. Till now, there are shortages remaining in extending solid tumor application of it, since the potential side effects, including CRS and neurotoxicity. These challenges limit clinical usage and more waiting to be solved. In this paper, we aim to introduce CAR-T therapy and optimize CAR design, improve manufacturing processes, and explore combination therapies to enhance the efficacy and safety of it.