Abstract
Exposure of rat paws to noxious heat (hot water, 48 degrees C) led to an increase in vascular permeability to macromolecules as indicated by extravasation of Evans blue dye. After pretreatment of neonatal rats with 50 mg X kg-1 capsaicin s.c., which is known to cause degeneration of unmyelinated afferent neurones, this protein leakage was reduced by 74% (P less than 0.01). It is concluded that the oedema induced by noxious heat is partially caused by excitation of peripheral endings of capsaicin-sensitive primary afferent neurones.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
