Abstract
In this review, we discuss the importance of capsaicin to the current understanding of neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We will focus on the analgesic effects of capsaicin and its clinical applicability in treating pain. Furthermore, we will draw attention to the rationale for other clinical therapeutic uses and implications of capsaicin in diseases such as obesity, diabetes, cardiovascular conditions, cancer, airway diseases, itch, gastric, and urological disorders.
Highlights
Capsaicin is a compound found in chili peppers and responsible for their burning and irritant effect
This work is a landmark in the mechanisms of pain since demonstrated that capsaicin induces pain-like behavior by activation of TRPV1 receptors expressed by nociceptors
Recent evidence demonstrated that a trans-membrane receptor called Tmem100 is co-expressed with both TRPV1-TRPA1 complex in dorsal root ganglion (DRG) neurons and is essential to modulate their activity by acting as an adaptor molecule [51]
Summary
Capsaicin is a compound found in chili peppers and responsible for their burning and irritant effect. Many recent studies have confirmed scientifically what was already known by some cultures: capsaicin can be used to relieve pain [1] This paradox can be seen with opioids, which have an established clinical use as analgesics, and induce hyperalgesia [2]. Despitethe the unpleasant unpleasantsensation sensationthat thatoccurs occurswhen whenlarge largequantities quantitiesof ofchili chilipeppers peppersare areconsumed, consumed, capsaicin when used in in thethe right dosage andand frequency. These properties caught the capsaicinpromotes promotespain painrelief relief when used right dosage frequency.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
