Abstract
With a rising prevalence of dementia around the world, there is an urgent need to identify opportunities for prevention. In The Lancet Neurology, Sam Norton and colleagues1 present a model that estimates the modifiable component of the risk of Alzheimer's disease in relation to seven key risk factors. Building on an earlier study by Barnes and Yaffe,2 they estimate that one in three Alzheimer's disease cases worldwide is attributable to diabetes, midlife hypertension, midlife obesity, physical inactivity, smoking, depression, or low educational attainment, taking into account the frequent co-occurrence of these factors.
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