Abstract
Epimers of N-oxides of morphine, codeine, thebaine, pseudomorphine and 2,2′-biscodeine were separated by capillary zone electrophoresis in the presence of cyclodextrins in bare silica or poly(vinyl alcohol)-coated capillaries in a background electrolyte with Tris–phosphate buffer, pH 2.8; diastereomers of thebaine N-oxide were separated also without cyclodextrins. γ-Cyclodextrin caused the highest resolution of epimers of morphine and codeine N-oxides, while separation of mono- and di- N-oxides of pseudomorphine and 2,2′-biscodeine without stereodifferentiation was best in the presence of 2,6-di- O-methyl-β-cyclodextrin. However, addition of the former cyclodextrin resulted also in separation of diastereomers of bismorphinane N-oxides.
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