Abstract
Polyamines and their regulatory synthetic enzyme ornithine decarboxylase (ODC) have been implicated in blood-brain barrier (BBB) breakdown following cryogenic injury. ODC activation and BBB breakdown are prevented by MK-801, indicating involvement of NMDA receptors. Studies in isolated rat cerebral capillaries supports the presence of NMDA receptors linked to ODC. NMDA (1–50 μM) stimulated capillary uptake of horseradish peroxidase, 2-deoxy-[ 14C]glucose, and 45Ca in a receptor-, concentration-, polyamine- and Ca 2+-dependent manner. We suggest that NMDA receptors may couple capillary transport of nutrients to glutamate-mediated neuronal excitation, and when overstimulated disrupt normal BBB function.
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