Abstract
BackgroundWe report hereby a severe case of Hantavirus Pulmonary Syndrome” (HPS) induced by Maripa virus in French Guiana and describe the mechanism of severity of the human disease.Case presentationA 47-year- old patient started presenting a prodromic period with fever, dyspnea, cough and head ache. This clinical presentation was followed by a rapid respiratory, hemodynamic and renal failure leading to admission in the ICU. Biological exams revealed an increased haematocrit level with a paradoxical low protein level. Echocardiographic and hemodynamic monitoring showed a normal left ventricular function with low filling pressures, an elevated extravascular lung water index and pulmonary vascular permeability index. These findings were compatible with a capillary leak-syndrome (CLS).ConclusionsThe severity of HPS caused by the virus Maripa in French Guiana can be explained by the tropism of hantavirus for the microvascular endothelial cell leading to a CLS.
Highlights
We report hereby a severe case of Hantavirus Pulmonary Syndrome” (HPS) induced by Maripa virus in French Guiana and describe the mechanism of severity of the human disease.Case presentation: A 47-year- old patient started presenting a prodromic period with fever, dyspnea, cough and head ache
The severity of HPS caused by the virus Maripa in French Guiana can be explained by the tropism of hantavirus for the microvascular endothelial cell leading to a capillary leak-syndrome (CLS)
This can result on a severe respiratory syndrome named ‘Hantavirus pulmonary syndrome’ (HPS) which can be associated to cardiac failure leading to ‘Hanta virus cardio-pulmonary syndrome’ (HCPS) [1]
Summary
We report hereby a severe case of Hantavirus Pulmonary Syndrome” (HPS) induced by Maripa virus in French Guiana and describe the mechanism of severity of the human disease.Case presentation: A 47-year- old patient started presenting a prodromic period with fever, dyspnea, cough and head ache. Conclusions: The severity of HPS caused by the virus Maripa in French Guiana can be explained by the tropism of hantavirus for the microvascular endothelial cell leading to a CLS. This can result on a severe respiratory syndrome named ‘Hantavirus pulmonary syndrome’ (HPS) which can be associated to cardiac failure leading to ‘Hanta virus cardio-pulmonary syndrome’ (HCPS) [1].
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