Abstract
Heart lesions similar to those seen in patients who have undergone thoracic radiotherapy were produced in young rabbits by a single 2,000-rad dose. Myocardium was studied during the latent period (two to seventy days) by light microscopy of 1μ epoxy sections, electron microscopy, and 3H-TdR radioautography. Endothelial cell damage, capillary narrowing, and microthrombi were seen at several points. Myocytes showed little damage. Endothelial cells were often 3H-TdR-labeled, while myocytes were not. Between thirty-nine and seventy days, labeled cells of irradiated myocardium increased significantly in number. In the late stage the ratio of capillaries to myocytes was reduced.
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