Abstract
BackgroundNo consensus has been reached on capillary blood reference intervals for platelet parameters in full-term neonates. We aimed to establish neonatal capillary blood reference intervals for platelet parameters and evaluate influences of sex, gestational age and postnatal age on platelet parameters.MethodsThis study was a prospective investigation and implemented in 594 healthy full-term neonates from 12 to 84 h of age, using SYSMEX XN-9000 haematology automatic analyser by means of capillary blood. Reference intervals for platelet parameters were defined by an interval of 2.5th − 97.5th percentiles.ResultsCapillary reference interval for platelet count was (152–464) × 109/L. No significance was found between sex-divided reference intervals for platelet parameters. The values of platelet count changed minimally across gestational age (37–41 weeks) and postnatal age (12–84 h). Reference intervals for other platelet parameters were affected by these factors to a different extent.ConclusionsWe established capillary blood reference intervals for platelet parameters in the first days after birth of full-term neonates in China.
Highlights
No consensus has been reached on capillary blood reference intervals for platelet parameters in fullterm neonates
Reference intervals (RIs) for platelet parameters are established in a healthy full-term neonate population and more than 120 specimens are required by the Clinical and Laboratory Standards Institute (CLSI) [14]
Platelet parameters reference intervals Totally 594 neonates were enrolled in present study
Summary
No consensus has been reached on capillary blood reference intervals for platelet parameters in fullterm neonates. We aimed to establish neonatal capillary blood reference intervals for platelet parameters and evaluate influences of sex, gestational age and postnatal age on platelet parameters. RIs for platelet parameters are established in a healthy full-term neonate population and more than 120 specimens are required by the Clinical and Laboratory Standards Institute (CLSI) [14]. The objectives of the present study were to determine capillary blood RIs for platelet count (PLT) and related parameters in 594 healthy full-term neonates from 12 to 84 h of age, and to evaluate influences of sex, gestational age and postnatal age on platelet parameters
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