Abstract
1. 1. The heptulose phosphate formed from nucleoside and from sugar phosphates (glucose 6-phosphate, mannose 6-phosphate, glucose 1-phosphate, fructose 6-phosphate and ribose 5-phosphate) by normal and thiamine-deficient rat tissues was measured under standard conditions. 2. 2. The thiamine-deficient rat exhibited a loss of activity of the enzymes synthesizing heptulose phosphate, particularly in brain, heart, kidney, spleen, lung and hemolysate. 3. 3. Addition of thiamine hydrochloride and thiamine pyrophosphate in vitro did not change the activity of tissue preparations from thiamine-deficient animals. 4. 4. In the presence of triose phosphate, supernatant preparations of thiamine-deficient hemolysate, kidney, liver and lung underwent as much as a three-fold increase in activity (substrates: glucose 6-phosphate, mannose 6-phosphate). The optimum concentration of triose phosphate was 2.5·10 −4.
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