Abstract
The authors consider the preparation of spheroids by extrusion-spheronization with Precirol ato 5 and Gelucire 50/02. The material is a ram extruder and a cylinder extruder associated to a spheronizer. Spheroids are obtained by adding an auxiliary substance such as microcrystalline cellulose. A comparison of the results obtained on the two types of extruder allows a better understanding of the pressure/displacement profile and emphasizes the necessary qualities of the wet mass and extrudates.
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