Abstract
Diabetes is a metabolic disorder disease associated with advanced glycation end products (AGEs) and protein glycation. The effect of polygonum cuspidatum extract (PE) on AGEs and Nε‐(Carboxymethyl)‐L‐lysine formation, protein glycation, and diabetes was investigated. Six primary phenolics in a range of 12.36 mg/g for ellagic acid to 0.01 mg/g for piceid were determined in PE. In an intermediate‐moisture‐foods model, inhibition rate of PE was as high as 54.2% for AGEs and 78.9% for CML under aw 0.75. The protein glycation was also inhibited by PE. In a diabetic rat model, the levels of blood glucose, serum malondialdehyde, cholesterol, triglycerides, and low‐density lipoproteins were effectively reduced by PE treatment. The antioxidation capacity (T‐AOC) and superoxide dismutase (SOD) activity were also mediated by PE. Additionally, the activates of liver function‐related enzymes including alkaline phosphatase (ALP), glutamate pyruvate transaminase (GPT), and glutamate oxaloacetate transaminase (GOT) in diabetic rat were improved by PE.
Highlights
Polygonum cuspidatum is an herbaceous perennial plant in the buckwheat and knotweed family Polygonaceae grown in Asia and North America (Zhang, Li, Kwok, Zhang, & Chan, 2013)
advanced glycation end products (AGEs) exert adverse effects on cell functions based on the mechanisms of free radicals production, protein or lipid fragmentation, enzyme activity alternation, and immunogenicity modification (Khangholi, Majid, Berwary, Ahmad, & Aziz, 2016)
A total of six primary phenolics including p‐coumaric acid, ellagic acid, piceid acid, coumarin, salicylic acid, and cinnamic acid were identified in polygonum extracts
Summary
Polygonum cuspidatum is an herbaceous perennial plant in the buckwheat and knotweed family Polygonaceae grown in Asia and North America (Zhang, Li, Kwok, Zhang, & Chan, 2013). AGEs exert adverse effects on cell functions based on the mechanisms of free radicals production, protein or lipid fragmentation, enzyme activity alternation, and immunogenicity modification (Khangholi, Majid, Berwary, Ahmad, & Aziz, 2016). It contributes to the development and progression of. The primary phenolics of polygonum and the potential of its extracts in AGE inhibition, and diabetes treatment were investigated in this study It will provide important information for further application of herbal polygonum as a natural therapy for pharmacological and drug development purpose
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