Abstract
AbstractThe mechanism of devitrification of racemic ibuprofen (RS‐IBP, C13H18O2) was analyzed by low‐wavenumber Raman spectroscopy (LWRS). This study shows the capabilities of LWRS to provide detailed new structural information, with respect to X‐ray diffraction data, on the atypical crystallization process of a molecular material (RS‐IBP) composed of a majority of hydrogen atoms. The conversions of Raman intensity into reduced intensity and Raman susceptibility were presented. The combination of these two types of spectrum representation reflecting the fast relaxational dynamics and the structural organization, respectively, has clearly revealed the high degree of disorder of Phase II. Additionally, Phase II was described as an early transient and metastable step of crystallization toward Phase I, from a deeply quenched liquid state. Analyzing the isothermal and nonisothermal crystallization has revealed two types of conversion of Phase II into Phase I, a solid–solid transformation and a crystallization of Phase I after melting of Phase II, respectively.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
