Abstract
It was reported by Jung and Day in 2011 that a cotton-like glass fiber pad made of borate glass 13-93B3 demonstrated a remarkable wound healing effect. It was approved for sale as a novel wound dressing in the management of acute and chronic wounds in 2016. However, the detailed mechanism of its wound healing effect has not been reported. In the present study, glass fibers of different composition in the system CaO-B2O3-SiO2 were prepared and their in vitro properties investigated to determine the role of the constituent components in wound healing. Fine glass fibers that were 0.6–2.0 μm in diameter were obtained by a melt blown method. However, these fibers were accompanied by small glass beads because of the low viscosity of the glass melts. 13-93B3 glass released an appreciable amount of borate and calcium ions into simulated body fluid (SBF). The amounts of these released ions decreased with partial replacement of the B2O3 in 13-93B3 with SiO2. The addition of large amounts of the borate and calcium ions into the culture medium decreased the viability of the L929 fibroblasts. Partial replacement of the B2O3 in 13-93B3 with SiO2 induced the formation of an apatite-like phase amenable to the adsorption of biological components on its surface in SBF. The wound healing effect of these glass fibers of different composition is worth examining in future animal experiments.
Highlights
Certain Na2O-CaO-SiO2-P2O5 glasses were found to bond to living bone by Hench et al in 1970 and named Bioglass® [1].Subsequently, various kinds of bone-bonding glasses and glass-ceramics have been derived from them
Fine glass fibers 0.6 to 2.0 μm in diameter of various composition in the system Na2O-K2O-MgO-CaO-B2O3-SiO2-P2O5 were prepared by a melt blown method
The melts of these various compositions were of a low viscosity above the liquidus temperature, and the glass fibers could not be formed from their melts without being accompanied by small glass beads
Summary
Various kinds of bone-bonding glasses and glass-ceramics have been derived from them Some of these have been successfully subjected to clinical applications as bone-repair materials [2]. It was found by Wilson in 1981 that Bioglass® can even bond to soft living tissues [3]. In 2011 Jung and Day demonstrated that a cotton-like glass fiber pad of borate glass named 13-93B3 that is composed of K2O, CaO and B2O3 exhibited a remarkable wound healing effect [4,5,6]. These glass fibers received USA FDA approval as a novel wound dressing in the management of acute and chronic wounds in 2016 [7]
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