Abstract
The purpose of this study is to review the impact of cannabis use on sexual functioning. The effects of cannabis on human sexuality have been known for centuries and explored for decades. The aphrodisiac effect of acute cannabis use has been frequently promoted, while the negative effect of its chronic use, especially in higher doses, has been less recognized and appreciated. The mechanism of cannabis effect on sexual functioning is not well understood, though results of some studies suggest a possible and controversial endocrinological explanation such as lowering of testosterone levels. Cannabis has bidirectional effect on sexual functioning. Low and acute doses of cannabis may enhance sexual human sexual functioning, e.g., sexual desire and enjoyment/satisfaction in some subjects. On the other hand, chronic use of higher doses of cannabis may lead to negative effect on sexual functioning such as lack of interest, erectile dysfunction, and inhibited orgasm. Studies of cannabis effect on human sexuality in cannabis users and healthy volunteers which would implement a double-blind design and use valid and reliable instruments are urgently needed in view of expanded use of cannabis/marijuana due to its legalization and medicalization.
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