Abstract
Background Cannabinoids and the endo-cannabinoid system play an important role in the sensation of pain. As conventional analgesics are often associated with serious side-effects, cannabinoids and agonists of their receptors offer a useful alternative or coanalgesic in the treatment of pain. The aim of this work is to summarize the role of cannabinoids and their receptors in nociception and pain treatment.
Highlights
Cannabinoids and the endo-cannabinoid system play an important role in the sensation of pain
As conventional analgesics are often associated with serious side-effects, cannabinoids and agonists of their receptors offer a useful alternative or coanalgesic in the treatment of pain
Materials and methods Two main types of receptors for cannabinoids and endo-cannabinoids are implicated in nociception: the metabotropic cannabinoid receptors and the ionotropic transient receptor potential channels TRP, which include the vanilloid receptors TRPV1, TRPV2, TRPV4 as well as TRPM8 and TRPA1
Summary
Cannabinoids and the endo-cannabinoid system play an important role in the sensation of pain. As conventional analgesics are often associated with serious side-effects, cannabinoids and agonists of their receptors offer a useful alternative or coanalgesic in the treatment of pain. The aim of this work is to summarize the role of cannabinoids and their receptors in nociception and pain treatment. Useful alterative option for pain management in clinical practice. Published: 22 April 2010 doi:10.1186/1744-859X-9-S1-S232 Cite this article as: Kara et al.: Cannabinoids in the treatment of pain. Annals of General Psychiatry 2010 9(Suppl 1):S232
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