Abstract
Introduction: Refractory epilepsies have a great impact in patients’ quality of life. Thus, studies with alternative drugs are extremely important to seek for effective treatments to control the condition, and cannabidiol (CBD) has shown promising results. Objectives: To analyze CBD’s efficacy as an alternative treatment of patients with refractory epilepsy. Design and setting: this study is a literature review from Universidade Federal da Bahia. Methods: We searched the following formula on PubMed: [cannabidiol] AND [epilepsy]. The inclusion criteria were clinical trials published from 2016-2021. Results: 25 articles were found, from which 18 were selected and, from those, 1092 patients were analyzed. All studies pointed to a reduction in frequency and/or intensity of epileptic crisis in adults and children with refractory epilepsy using CBD, independently of the etiology. In Laux’s study, they noted reductions of 50% and 44% in motor and total seizures (respectively). Moreover, Birnbaum’s study showed that using CBD with a meal may cause variability of exposure of patients to the drug. Adverse effects were dose dependent, mainly diarrhea, sleepiness and less appetite. The interaction between CBD and anticonvulsants was not shown to have a prejudicial or neutralizing effect. Conclusion: CBD was shown to be capable of attenuating attacks in patients with refractory epilepsy. However, more randomized clinical trials are needed to analyze the efficacy and the safety of these medications in the short and long term.
Highlights
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack
The present review study aimed to address the mechanisms of action of capsaicin and other chemical inducers in mast cell degranulation and an interaction of nerves and events that happen in the dura mater with the activation of mast cells
Conclusion: the analyzed data indicate that the polymorphisms contributed to the susceptibility to Parkinson’s disease (PD), further studies related to the polymorphisms and their relationship to PD are still needed for more ethnic groups, and early diagnosis is possible
Summary
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack. Methods: A literature review and an observational, descriptive and transversal data collect on treatment for acute demyelinating polyradiculoneuritis, available at DATASUS from January 2008 to December 2020, and articles available at Scielo and PubMed. Results: There were 7,917 hospitalizations, representing a total expenditure of R$ 9,392,552.04, 2009 being the year with the highest number of hospitalizations (809) and 2017 with the highest amount spent during the period (R$ 967,284.65). Methods: A literature review and an observational, descriptive and transversal data collect on surgical treatment was carried out, available from January 2008 to December 2020 and articles available in Scielo, Lilacs and PubMed. Results: There were 15,148 hospitalizations for surgical procedures for the treatment of chronic subdural hematoma, representing a total expenditure of R$ 45,365,258.21, with 2018 being the year with the highest number of hospitalizations (1,418) and with the highest amount spent during the period (R$ 4,570,334.28). Conclusions: The “Coca-Cola Bottle sign” is a classic sign of Graves’ disease, some signs, such as, unilateral and single orbital musculature involvement, may be suggestive of involvement by other etiologies, suggesting the benefit of an early expanded investigation
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
