Abstract
Based on previous observations that cannabidiol (CBD) blocks some effects of Δ 9-tetrahydrocannabinol ( Δ 9-THC) in laboratory animals, the present work was carried out to study possible interaction between CBD and Δ 9-THC in human beings. In a double blind procedure, 40 healthy male volunteers were assigned to 1 of 8 experimental groups, receiving per oral route, placebe, 30 mg Δ 9-THC, 15 30 or 60 mg of CBD, and mixtures of 30 mg of Δ 9-THC plus either 15, 30 or 60 mg of CBD respectively. Pulse rate, time production tasks and psychological logical reactions were measured at several time intervals after drug ingestion. 30 mg Δ 9-THC alone increased pulse rate, disturbed time tasks and induced strong psychological reactions in the subjects. 15–60 mg of CBD alone provoked no effects. On the other hand, CBD was efficient in blocking most of the effects of Δ 9-THC when both drugs were given together. CBD also decreased the anxiety component of Δ 9-THC effects, in such a way that the subjects reported more pleasurable effects.
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