Abstract
Mutations in members of voltage-gated potassium channel family 7 (Kv7) modify electrophysiological properties and cause distinct clinical presentations. Mutations of the M-channel (Kv7.2/3 heterotetramer) underlying the neuronal M-current cause benign familial neonatal epilepsy (BFNE). Mutations in the Kv7.1 or KCNE1 subunit of the Kv7.1/KCNE1 heteromultimer underlying the ventricular repolarization current IKS cause Long-(L)QT-syndrome. The phytocannabinoid cannabidiol (CBD) is an FDA-approved anticonvulsant.
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