Abstract
A new renal perfusate, which closely resembles intracellular electrolyte composition and is made hyperosmolar with mannitol, was successfully used without additives to preserve canine kidneys for up to 72 hours after initial perfusion and hypothermic storage. The technique allows renal viability for periods that compare favourably with those previously obtained with constant perfusion and hypothermia. The new perfusate was also successful in protecting the ischæmic canine kidney from the otherwise irreversibly damaging effects of 2 and 3 hours' normothermic exposure " in vivo ", and was successfully used to protect the ischæmic kidney for 3 hours without continuous cooling during " workbench " surgery.
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