Canine fetus immune system at late development.

Kelly Cristine Santos Roballo,Carlos Eduardo Ambrósio,Daniele Dos Santos Martins,Aline Fernanda Souza,Valéria Maria Lara,Alessandra Oliveira Pinheiro,Luciana Cristina Machado,Rafael Garcia Karam,Ingrid Da Silva Gomes

doi:10.21451/1984-3143-ar2019-0004

Kelly Cristine Santos Roballo, Carlos Eduardo Ambrósio + Show 7 more

Open Access

https://doi.org/10.21451/1984-3143-ar2019-0004

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Journal: Animal Reproduction	Publication Date: Jan 1, 2019
Citations: 1	License type: cc-by

Affiliation: Universidade de São Paulo

Abstract

The immune system is mainly responsible for protecting the organism against agents that may interfere in its homeostasis. Thus, understand how this system develops and operates is very important, for create new therapies to assist this system in its operation, such as its failure. In domestic dogs, few studies show how actually occurs the development, maturation and functioning of the immune system. Therefore, this study demonstrates the development and possible activation of it on dog fetus from late gestational period by in situ and microscopic analyzes.

Highlights

Embryonic development is the study of early life and its changes through the prenatal period (Moore and Persaud, 2008)
The study of development can be divided according to the changes that occur during this period, such as the embryonic stage when most organs and systems are established and the fetal period, which is the growth and improvement of organs (Hyttel et al, 2010; Martins et al, 2011), the characterization of the embryonic and fetal development is divided according to the changes that occurred during that period (Miglino et al, 2006; Pretzer, 2008)
The lymph node was connected and close to the thymus with less than 0.4 mm of length with afferent lymph vessels, subcapsular sinus, endothelial cells, and lymphocytes, there was no evidence of cortex and medullar region at this fetal period (Fig. 1C-D)

Summary

Introduction

Embryonic development is the study of early life and its changes through the prenatal period (Moore and Persaud, 2008). Dog’s immune system still not well described, but in general, it consists of an intricate network of molecules, cells and organs that are responsible for protecting the body against mostly microorganisms, tumors, and traumas (Miglino et al, 2006; Tizard, 2014). Specialized cells such as macrophages, neutrophils, dendritic cells, natural killer cells, lymphocytes, and components produced by them are part of this system, which is divide in innate and acquire immunity (Hyttel et al, 2010; Abbas et al, 2014). The thymus, bone marrow and Peyer’s patch are primary lymphoid organs regulating the initial development and maturation of the immune cells (Hyttel et al, 2010)

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