Abstract
BackgroundInfectious canine hepatitis is a rarely encountered disease, that is caused by Canine Adenovirus-1. Clinical signs can vary dramatically, and neurological signs are rarely seen. Neurological manifestation of this disease is rarely reported in the veterinary literature.Case presentationA 5-week-old, male entire Husky cross puppy presented for a one-day history of abnormal neurological behaviour (circling, ataxia, vocalization and obtund mentation). The puppy was euthanized shortly after presentation due to rapid deterioration. Histopathology raised concerns for Canine Adenovirus 1 (CAdV-1) based on vasculitis in the brain and intranuclear inclusion bodies in endothelial cell and hepatocytes; immunohistochemistry on brain tissue confirmed CAdV-1 infection.ConclusionsThis report discusses possible routes of infection and manifestations of adenovirus infections causing neurologic signs. It also provides a timely reminder that CAdV-1 should be considered a differential in unvaccinated dogs that present with neurological signs. Further studies are required to better understand the neurotrophic tendencies of this virus.
Highlights
Infectious canine hepatitis is a rarely encountered disease, that is caused by Canine Adenovirus-1
It provides a timely reminder that Canine Adenovirus 1 (CAdV-1) should be considered a differential in unvaccinated dogs that present with neurological signs
We describe a rare case of infectious canine hepatitis associated with neurological abnormalities in a puppy
Summary
This report discusses possible routes of infection and manifestations of adenovirus infections causing neurologic signs.
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