Abstract
Invasive candidiasis is an infrequent, yet life-threatening infection among HIV-infected children. The treatment of choice are amphotericin B formulations and alternatively fluconazole. Good penetration to the central nervous system of both drugs makes such therapy a reasonable solution for this specific group of patients. Echinocandins, mainly due to their outstanding safety profile, alongside with clinical effectiveness, are still a second-line treatment and further research is required to assess their role as antifungal agents used in management of Candida infections in HIV-infected children. However, they are the first-line antifungal agents in other groups of patients according to recently published guidelines.
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